LL-37 is a naturally occurring antimicrobial peptide produced by the body as part of the innate immune system. It plays a critical role in immune defense by helping the body identify and neutralize bacteria, viruses, and fungi, while also regulating inflammation and supporting tissue repair.
LL-37 also helps maintain immune balance—supporting the immune response without overstimulation. Over time, factors such as aging, chronic stress, hormonal changes, recurrent illness, or immune dysfunction can reduce natural LL-37 production. When levels are low, individuals may experience increased infections, persistent inflammation, slower healing, and chronic fatigue.
LL-37 therapy is designed to support and enhance the body’s existing immune pathways. Rather than suppressing immune activity or relying on repeated antibiotic use, LL-37 works by improving immune signaling, pathogen defense, and inflammatory regulation under medical supervision.
LL-37 has been studied for its broad immune-supportive properties, including:
LL-37 supports the immune system’s ability to recognize and respond to pathogens more effectively.
LL-37 helps regulate inflammatory signaling, which may reduce chronic or excessive inflammation without suppressing immune function.
This peptide plays a role in tissue regeneration and repair, supporting recovery from injury, infection, or inflammation.
LL-37 supports intestinal barrier integrity and microbiome balance, which are essential for immune health, digestion, and systemic inflammation control.
LL-37 demonstrates broad-spectrum antimicrobial activity, making it a versatile immune-supportive therapy.
LL-37 may help individuals who experience frequent sinus, respiratory, urinary, skin, or gastrointestinal infections
By supporting cellular turnover and inflammatory balance, LL-37 may improve skin resilience and healing.
Overall, LL-37 helps the immune system respond appropriately—supporting defense and recovery without excessive reactivity.
LL-37 therapy may be appropriate for individuals experiencing signs of immune imbalance or chronic inflammation. Potential candidates may include those with:
Chronic or systemic inflammation
Recurrent infections (sinus, respiratory, urinary, skin, or gut-related)
Slow healing following illness or injury
Digestive symptoms related to dysbiosis or inflammation
Autoimmune tendencies or immune dysregulation
Persistent fatigue or reduced immune resilience
Chronic inflammatory skin conditions
Immune changes related to hormonal transitions
LL-37 may also be considered for proactive immune support in individuals with high physical, environmental, or lifestyle immune demands.
LL-37 therapy is not intended to overstimulate the immune system, but rather to help restore appropriate immune regulation.
LL-37 may support immune balance and recovery in a variety of conditions where infection or inflammation is a contributing factor, including:
Chronic Sinus Infections
Respiratory Conditions such as chronic cough or post-viral inflammation
Gut Conditions including dysbiosis, leaky gut, or chronic inflammation
Skin Conditions such as acne, eczema, psoriasis, or delayed healing
Autoimmune-Related Inflammation (as supportive care, not a cure)
Chronic UTIs or Recurrent Vaginal Infections
Delayed Wound Healing
Post-Infection Recovery involving prolonged fatigue or inflammation
Treatment suitability is determined on an individual basis by a licensed medical provider.
Before starting peptide therapy, certain lifestyle strategies may help support immune function and natural LL-37 production:
A nutrient-dense diet including lean proteins, vegetables, omega-3 fatty acids, and fermented foods supports immune balance.
Regular exercise supports immune health, hormonal balance, and inflammation regulation.
Chronic stress negatively affects immune signaling. Stress reduction through mindfulness, movement, or routine balance may be beneficial.
Adequate, high-quality sleep is essential for immune regulation and tissue repair.
Adequate fiber intake, hydration, and microbiome support are critical for immune-gut communication.
If these measures are in place and symptoms persist, medical evaluation may be appropriate.
At BHRT Delivered, we use a structured, medical approach to determine whether LL-37 therapy is appropriate.
A licensed provider reviews symptoms, medical history, lifestyle factors, and health goals.
When indicated, laboratory testing may assess inflammation markers, immune function, gut health, hormone balance, and nutrient status.
If LL-37 is appropriate, a customized plan is developed based on individual biology and clinical findings.
Patients are monitored throughout treatment to assess response, adjust dosing, and ensure safe, steady progress.
LL-37 is a clinically studied antimicrobial peptide with broad immune-supportive properties. When used under medical supervision, it may help restore immune balance, reduce chronic inflammation, and support recovery from infection or immune dysfunction.
Through convenient telehealth care, BHRT Delivered provides personalized, evidence-based immune support focused on safety, regulation, and long-term resilience.
